Research

Cardiovascular risk in Chronic Kidney Disease

Cardiovascular mortality is the leading cause of death in Chronic kidney disease patients and traditional risk factors do not fully explain the 10-40 times increased risk in kidney patients. We use our expertise in metabolomics and proteomics on animal and clinical studies to demonstrate the role of heme enzyme myeloperoxidase in oxidizing vascular wall proteins and high density lipoprotein making them dysfunctional.

Salt Sensitive Hypertension in Chronic Kidney Disease

Salt sensitivity and hypertension are risk factors for Chronic Kidney Disease progression, but very little evidence exists on the metabolic basis and role of salt sensitivity in kidney disease. We aim to delineate the metabolic markers associated with salt sensitivity in kidney patients using targeted metabolomics in animal and clinical studies.

Metabolic Determinants of Diabetic Kidney Disease

Diabetic kidney disease remains the primary cause of end-stage renal disease. We explore the metabolic determinants of the diabetic kidney disease using a targeted metabolomics and mechanistic animal metabolic flux studies to demonstrate the patho-physiological roles of these metabolites in disease process.