Research

Cardiovascular risk in Chronic Kidney Disease

Cardiovascular mortality is the leading cause of death in Chronic kidney disease patients and traditional risk factors do not fully explain the 10-40 times increased risk in kidney patients. We use our expertise in metabolomics and proteomics on animal and clinical studies to demonstrate the role of heme enzyme myeloperoxidase in oxidizing vascular wall proteins and high density lipoprotein making them dysfunctional.

Salt Sensitive Hypertension in Chronic Kidney Disease

Salt sensitivity and hypertension are risk factors for Chronic Kidney Disease progression, but very little evidence exists on the metabolic basis and role of salt sensitivity in kidney disease. We aim to delineate the metabolic markers associated with salt sensitivity in kidney patients using targeted metabolomics in animal and clinical studies.

Metabolic Determinants of Diabetic Kidney Disease

Diabetic kidney disease remains the primary cause of end-stage renal disease. We explore the metabolic determinants of the diabetic kidney disease using a targeted metabolomics and mechanistic animal metabolic flux studies to demonstrate the patho-physiological roles of these metabolites in disease process.

Funding Sources

NIH, National Heart Lung and Blood Institute

George O'Brien Michigan Kidney Translational Core Center Pilot and Feasibility Grant

Michigan Nutrition and Obesity Research Center Pilot and Feasibility Grant

Michigan Proteomics Resource Facility Pilot and Feasibility Grant

University of Michigan ADVANCE program Elizabeth Caroline Crosby Award

University of Michigan Geriatric and Palliative Care Medicine -Pilot and Exploratory Studies Core (PESC)

Michigan Institute for Clinical and Health Research (MICHR)

Collaborators

University of Michigan

Dr. Subramaniam Pennathur (Neph)

Dr. Pavan Reddy (Hem-Onc)

Dr. Rajiv Saran (Neph)

Dr. Brenda Gillespie (SPH)

Dr. Rodica Pop-Busui (MEND)



Dr. Farsad Afshinnia (Neph)

Dr. Laura Mariani (Neph)

Dr. Mathias Kretzler (Neph)

Dr. Robert Brooks (Cardiology)

National

Dr. Kumar Sharma (UTHSCSA)

International

Dr. Anne-Emiliee Decleves (Universite de Mons, Belgium)